Foods with polyamines can potentially treat age-related diseases and increase longevity

Every human being is born with his own internal clock that determines whether this person is a morning bird or a night owl. As people age, this clock starts slowing down, which can cause developing of many age-related diseases. According to the researchers, there is a tight connection between circadian rhythm and metabolism, and that even tiny changes in a person’s circadian rhythm can be linked to a wide variety of metabolic and age-related diseases, such as cancer, Alzheimer’s disease, Parkinson’s disease, inflammation, etc. But there is good news. Recently the researchers have made a new interesting discovery. Almost every cell in our bodies is full with compounds called polyamines. They play an important role in the body’s internal clock and regulate cell growth and death. So the researchers discovered that polyamines taken as supplements may be able to stave off age-related diseases and even increase longevity.

As people age, their internal clock starts slowing down, and it becomes more likely to develop new diseases. These rhythms are very complex and affect numerous activities in the brain, that’s why researchers are only now discovering these processes. According to them, even smallest changes in a person’s circadian rhythm can be related to metabolic and age-related diseases.

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During their researches, scientists treated a group of young mice with a medicine that stops the body from processing polyamines. That caused their circadian rhythms to slow down by roughly eleven minutes with each passing day, compared to young mice that processed polyamines normally, without drugs. Also, the scientists gave some adult mice drinking water containing spermidine, the edible form of polyamines usually found in foods, like soybeans, corn, green peas, and blue cheese. Their circadian rhythms thus sped up to about 8 minutes faster than untreated adult mice, ultimately returning it back to normal. So the researchers believe this effect can help suppress age-related diseases.

This hasn’t been tested and proven in humans yet, though. There is evidence in flies and mice that polyamines extend lifespan, and future studies might also support the use of polyamines in humans. But the researchers believe that testing polyamines in clinical trials can be an effective tool against a wide variety of age-related diseases in humans. This discovery opens new great possibilities, such as the ability to repair the internal clock through nutritional intervention (polyamine supplementation).

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